A new urinary catheter design reduces in-vitro biofilm formation by influencing hydrodynamics

SummaryAim To evaluate the performance of a new catheter design based on different hydrodynamics aiming to reduce development biofilm, and compare it with conventional Foley (FC). Methods The proposed (NPD) is modification FC, asymmetric positioning balloon additional drainage holes allowing continuous urine complete voiding bladder. A first experiment was undertaken assess capability, second performed using bioreactor set-up simulating bladder test as flow-through system. biofilm formation five bacterial species associated catheter-associated urinary tract infection (CAUTI) determined after 24 h incubation an MTT assay. Morphological evaluation scanning electron microscopy. In-vitro determination residual fluid, quantitative morphological data intravesical intraluminal parts tested catheters were assessed. Results Residual fluid significantly higher in FC (5.60 ± 0.43 mL) compared NPD (0.2 0.03 mL). showed less (P<0.0001) than FC. Catheter had variable effect depending strain tested. There biomass both (P<0.0001). Multi-layered biofilms that covered surfaces completely seen for all strains, while reduced formation. Conclusions Modifications hydrodynamic characteristics can colonization. Integrated approaches combining chemical, mechanical topographical elements help occurrence CAUTI.